BDBM463344 N-[2-(3-chloro-4-fluorophenoxy)ethyl]-3-(methoxymethyl)-1-({4-[(2-oxopyridin-1-::US10781181, Example 12

SMILES COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCCOc1ccc(F)c(Cl)c1

InChI Key InChIKey=YUQJMTWNZZCIDE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463344   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463344(N-[2-(3-chloro-4-fluorophenoxy)ethyl]-3-(methoxyme...)
Affinity DataIC50: >1.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463344(N-[2-(3-chloro-4-fluorophenoxy)ethyl]-3-(methoxyme...)
Affinity DataIC50:  266nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent