BDBM463356 N-[2-(3-chlorophenoxy)ethyl]-3-cyano-1-({4-[(2-oxopyridin-1-::US10781181, Example 38

SMILES Clc1cccc(OCCNC(=O)c2cn(Cc3ccc(Cn4ccccc4=O)cc3)nc2C#N)c1

InChI Key InChIKey=KPMIBBMTUQEJQB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463356   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463356(N-[2-(3-chlorophenoxy)ethyl]-3-cyano-1-({4-[(2-oxo...)
Affinity DataIC50: >4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463356(N-[2-(3-chlorophenoxy)ethyl]-3-cyano-1-({4-[(2-oxo...)
Affinity DataIC50:  6.5nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent