BDBM463407 3-amino-N-[2-(3-chlorophenoxy)ethyl]-1-({4-[(3-methyl-2-oxopyridin-1-::US10781181, Example 85

SMILES Cc1cccn(Cc2ccc(Cn3cc(C(=O)NCCOc4cccc(Cl)c4)c(N)n3)cc2)c1=O

InChI Key InChIKey=LXROWPJGZHKOKV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463407   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463407(3-amino-N-[2-(3-chlorophenoxy)ethyl]-1-({4-[(3-met...)
Affinity DataIC50: >4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463407(3-amino-N-[2-(3-chlorophenoxy)ethyl]-1-({4-[(3-met...)
Affinity DataIC50:  3.5nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent