BDBM463425 3-amino-N-[2-(3-chlorophenoxy)ethyl]-1-({5-[(2-oxopyridin-1-yl)methyl]pyridin-2-::US10781181, Example 102

SMILES Nc1nn(Cc2ccc(Cn3ccccc3=O)cn2)cc1C(=O)NCCOc1cccc(Cl)c1

InChI Key InChIKey=CPRWTCGSTDZPML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463425   

TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463425(3-amino-N-[2-(3-chlorophenoxy)ethyl]-1-({5-[(2-oxo...)
Affinity DataIC50: >4.00E+4nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods. Human KLK1 (Callbiochem) was incubated at 25° C. with the fluoroge...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM463425(3-amino-N-[2-(3-chlorophenoxy)ethyl]-1-({5-[(2-oxo...)
Affinity DataIC50:  72.1nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods. Human plasma kallikrein (Protogen) was incubated at 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent