BDBM464260 3-(4-(1H-pyrazol-4- yl)phenyl)-8-(2- hydroxyethyl)-1-(3- methoxybenzyl)- 1,3,8- triazaspiro[4.5]decan- 2-one::US10787450, Example 141

SMILES COc1cccc(CN2C(=O)N(CC22CCN(CCO)CC2)c2ccc(cc2)-c2cn[nH]c2)c1

InChI Key InChIKey=WVZRXGWIIFZFHK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464260   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464260(3-(4-(1H-pyrazol-4- yl)phenyl)-8-(2- hydroxyethyl)...)
Affinity DataIC50: <3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent