BDBM464320 8-(3,3- difluorocyclobutane- carbonyl)-3-(6-ethyl-5- (1H-pyrazol-4- yl)pyridin-2-yl)-1-(3- methoxybenzyl)- 1,3,8- triazaspiro[4.5]decan- 2-one::US10787450, Example 202

SMILES CCc1nc(ccc1-c1cn[nH]c1)N1CC2(CCN(CC2)C(=O)C2CC(F)(F)C2)N(Cc2cccc(OC)c2)C1=O

InChI Key InChIKey=COBLGTTVCMEWFD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464320   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464320(8-(3,3- difluorocyclobutane- carbonyl)-3-(6-ethyl-...)
Affinity DataIC50: <3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent