BDBM464515 Preparation of 1-(1-cyclopropyl-3-butenylsulfonyl)-N-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide ::US10793549, Compound G-2

SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1

InChI Key InChIKey=OVBVSKMULHRPLN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 464515   

TargetHistone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM464515(Preparation of 1-(1-cyclopropyl-3-butenylsulfonyl)...)
Affinity DataIC50:  14nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM464515(Preparation of 1-(1-cyclopropyl-3-butenylsulfonyl)...)
Affinity DataIC50:  2.36E+5nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University

Curated by ChEMBL
LigandPNGBDBM464515(Preparation of 1-(1-cyclopropyl-3-butenylsulfonyl)...)
Affinity DataIC50:  14nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed