BDBM464515 Preparation of 1-(1-cyclopropyl-3-butenylsulfonyl)-N-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide ::US10793549, Compound G-2
SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c2c(C)cn(c2c1)S(=O)(=O)C1(CC=C)CC1
InChI Key InChIKey=OVBVSKMULHRPLN-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 464515
TargetHistone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology
US Patent
Shanghai Haiyan Pharmaceutical Technology
US Patent
Affinity DataIC50: 14nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 2.36E+5nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affiliated Hospital Of Guangdong Medical University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair