BDBM464566 Preparation of 1-(1-allylcyclopropylsulfonyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(4-methylpiperazin-1-yl) piperidin-1-yl)-1H-indole-4-carboxamide ::US10793549, Compound G-69
SMILES COc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(cc(C)c12)S(=O)(=O)C1(CC=C)CC1)N1CCN(C)CC1
InChI Key InChIKey=OPDSDRNDYJKMNU-UHFFFAOYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 464566
TargetHistone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology
US Patent
Shanghai Haiyan Pharmaceutical Technology
US Patent
Affinity DataIC50: 26nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...More data for this Ligand-Target Pair