BDBM464656 CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-3-[2-(3-hydroxy-oxetan- 3-yl)-ethyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one::US10793556, Example SC_4083::US10793556, Example SC_4084::US10793556, Example SC_4085::US10793556, Example SC_4086::US10793556, Example SC_4087::US10793556, Example SC_4088

SMILES CN(C)[C@]1(CC[C@]2(CN(CC(C)(C)NS(C)(=O)=O)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1

InChI Key InChIKey=VNMHBZDHRNEGCC-OGLKEZPNSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 464656   

TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  3nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  6nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  6nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  10nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  12nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  118nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  235nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  495nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  535nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  570nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  935nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
Gruenenthal

US Patent
LigandPNGBDBM464656(CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-meth...)
Affinity DataKi:  2.47E+3nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent