BDBM466378 (8S)-N-[(2S)-2-(5- cyano-2-pyridyl)- 2-hydroxy-ethyl]- 5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- 5-azaspiro [2.5]octane- 8-carboxamide::US10799507, Example 36

SMILES O[C@@H](CNC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)c1ccc(cn1)C#N

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466378   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466378((8S)-N-[(2S)-2-(5- cyano-2-pyridyl)- 2-hydroxy-eth...)
Affinity DataEC50:  2nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466378((8S)-N-[(2S)-2-(5- cyano-2-pyridyl)- 2-hydroxy-eth...)
Affinity DataEC50:  70.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466378((8S)-N-[(2S)-2-(5- cyano-2-pyridyl)- 2-hydroxy-eth...)
Affinity DataEC50:  25.2nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466378((8S)-N-[(2S)-2-(5- cyano-2-pyridyl)- 2-hydroxy-eth...)
Affinity DataEC50:  8.70nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent