BDBM466383 (8S)—N-[(1S,2R)-2-(5-Fluoro-2-Pyridyl)-2-Hydroxy-1-Methyl-Ethyl]-5-(7H-Pyrrolo[2,3-d]Pyrimidin-4-Yl)-5-Azaspiro[2.5]Octane-8-Carboxamide::US10799507, Example 41

SMILES C[C@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)[C@@H](O)c1ccc(F)cn1

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466383   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466383((8S)—N-[(1S,2R)-2-(5-Fluoro-2-Pyridyl)-2-Hydroxy-1...)
Affinity DataEC50:  2.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466383((8S)—N-[(1S,2R)-2-(5-Fluoro-2-Pyridyl)-2-Hydroxy-1...)
Affinity DataEC50:  33.5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466383((8S)—N-[(1S,2R)-2-(5-Fluoro-2-Pyridyl)-2-Hydroxy-1...)
Affinity DataEC50:  48.9nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466383((8S)—N-[(1S,2R)-2-(5-Fluoro-2-Pyridyl)-2-Hydroxy-1...)
Affinity DataEC50:  5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent