BDBM466400 N-[[1- (hydroxymethyl) cyclopentyl]methyl]- 5-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 5-azaspiro [2.5]octane- 8-carboxamide::US10799507, Example 58

SMILES OCC1(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)CCCC1

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466400   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466400(N-[[1- (hydroxymethyl) cyclopentyl]methyl]- 5-(7H-...)
Affinity DataEC50:  4.10nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466400(N-[[1- (hydroxymethyl) cyclopentyl]methyl]- 5-(7H-...)
Affinity DataEC50:  142nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466400(N-[[1- (hydroxymethyl) cyclopentyl]methyl]- 5-(7H-...)
Affinity DataEC50:  30.3nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466400(N-[[1- (hydroxymethyl) cyclopentyl]methyl]- 5-(7H-...)
Affinity DataEC50:  13nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent