BDBM466418 Benzyl (2R)-3-Hydroxy-2-[[(8S)-5-(7H-Pyrrolo[2,3-d]Pyrimidin-4-Yl)-5-Azaspiro[2.5]Octane-8-Carbonyl]Amino]Propanoate::US10799507, Example 80

SMILES OC[C@@H](NC(=O)[C@H]1CCN(CC11CC1)c1ncnc2[nH]ccc12)C(=O)OCc1ccccc1

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466418   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466418(Benzyl (2R)-3-Hydroxy-2-[[(8S)-5-(7H-Pyrrolo[2,3-d...)
Affinity DataEC50:  6.70nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466418(Benzyl (2R)-3-Hydroxy-2-[[(8S)-5-(7H-Pyrrolo[2,3-d...)
Affinity DataEC50:  119nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466418(Benzyl (2R)-3-Hydroxy-2-[[(8S)-5-(7H-Pyrrolo[2,3-d...)
Affinity DataEC50:  24.3nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466418(Benzyl (2R)-3-Hydroxy-2-[[(8S)-5-(7H-Pyrrolo[2,3-d...)
Affinity DataEC50:  21.8nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent