BDBM46658 1,2-benzothiazol-3-one::MLS-0254244.0001::US9011882, Table 1, Compound 20::acs.jmedchem.1c00409_ST.166::cid_17520

SMILES O=c1[nH]sc2ccccc12

InChI Key InChIKey=DMSMPAJRVJJAGA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 46658   

TargetPhosphomannomutase 2(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50: >1.00E+5nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetMannose-6-phosphate isomerase(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50: >5.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50:  1.22E+4nMAssay Description:Data Source: Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute Network...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Homo sapiens (Human))
The Board Of Trustees Of The Leland Stanford Junior University

US Patent
LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50:  1.32E+4nMAssay Description:The L-citrulline assay was based upon an original test-tube method developed by Prescott and Jones in 1969 (Prescott, L. M. & Jones, M. E. Modified m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
Michigan State University

LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50:  660nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Tianjin University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50:  1.37E+5nMAssay Description:Inhibition of human recombinant caspase-7 using Ac-DEVD-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50:  4.67E+4nMAssay Description:Inhibition of recombinant human caspase-3 using Ac-LDEVD-AMC as substrate assessed as accumulation of 7-AMC incubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50:  307nMAssay Description:Inhibition of recombinant rat MGL expressed in human HeLa cells using 2-oleoylglycerol as substrate preincubated for 10 mins followed by substrate ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Nankai University

Curated by ChEMBL
LigandPNGBDBM46658(1,2-benzothiazol-3-one | MLS-0254244.0001 | US9011...)
Affinity DataIC50:  4.67E+4nMAssay Description:Inhibition of human recombinant caspase-3 using Ac-LDEVD-AMC as substrate after 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed