BDBM466600 US10800757, Compound 16::US10889568, Compound 16::[4-(6-Amino-pyridazin-3-yl)- piperidin-1-yl]-(4-methoxy-5- phenoxy-pyridin-2-yl)-methanone

SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCC(CC1)c1ccc(N)nn1

InChI Key InChIKey=PYYOCJNMFRDSEU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466600   

TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466600(US10800757, Compound 16 | US10889568, Compound 16 ...)
Affinity DataIC50:  27nMAssay Description:This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466600(US10800757, Compound 16 | US10889568, Compound 16 ...)
Affinity DataIC50:  27nMAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent