BDBM466639 US10800757, Compound 55::US10889568, Compound 55::[(R)-4-(6-Amino-4-methoxy-pyridin-3- yl)-2-methoxymethyl-piperazin-1-yl]- [5-(4-fluoro-phenoxy)-4-methoxy- pyridin-2-yl]-methanone

SMILES COC[C@H]1CN(CCN1C(=O)c1cc(OC)c(Oc2ccc(F)cc2)cn1)c1cnc(N)cc1OC

InChI Key InChIKey=PRXXVKZSFZOPQS-QGZVFWFLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466639   

TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466639(US10800757, Compound 55 | US10889568, Compound 55 ...)
Affinity DataIC50:  220nMAssay Description:This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466639(US10800757, Compound 55 | US10889568, Compound 55 ...)
Affinity DataIC50:  220nMAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent