BDBM466910 2-(2-{6-Chloro-1H- pyrrolo[2,3-b]pyridin-4-yl}- 6-[(3R)-3-methylmorpholin- 4-yl]pyrimidin-4-yl)-6-ethyl- 1lambda6,2,6-thiadiazinane-1,1- dione::US10800774, Example 9

SMILES CCN1CCCN(c2cc(nc(n2)-c2cc(Cl)nc3[nH]ccc23)N2CCOC[C@H]2C)S1(=O)=O

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466910   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM466910(2-(2-{6-Chloro-1H- pyrrolo[2,3-b]pyridin-4-yl}- 6-...)
Affinity DataIC50:  115nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM466910(2-(2-{6-Chloro-1H- pyrrolo[2,3-b]pyridin-4-yl}- 6-...)
Affinity DataIC50:  570nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent