BDBM466935 US10800775, Example 9::ethyl 4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H- pyrazol-4-yl)-1H-pyrrolo[2,3b]pyridine-5-carboxylate

SMILES CCOC(=O)c1cnc2[nH]ccc2c1-c1cnn(c1)C1(CC#N)CN(C1)S(=O)(=O)CC

InChI Key InChIKey=ACWFRCADQXAJPO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466935   

TargetTyrosine-protein kinase JAK3 [781-1124](Homo sapiens (Human))
Aclaris Therapeutics

US Patent
LigandPNGBDBM466935(US10800775, Example 9 | ethyl 4-(1-(3-(cyanomethyl...)
Affinity DataIC50:  55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Aclaris Therapeutics

US Patent
LigandPNGBDBM466935(US10800775, Example 9 | ethyl 4-(1-(3-(cyanomethyl...)
Affinity DataIC50: <10nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent