BDBM466958 Methyl 3-Chloro-4-(8-chloro- 3-((2,2-difluorocyclopropyl) methyl)-[1,2,4]triazole[4,3-a] pyridine-7-yl)benzoate::US10800776, Example 46

SMILES COC(=O)c1ccc(c(Cl)c1)-c1ccn2c(CC3CC3(F)F)nnc2c1Cl

InChI Key InChIKey=OWZFYFLHUWCLSJ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466958   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM466958(Methyl 3-Chloro-4-(8-chloro- 3-((2,2-difluorocyclo...)
Affinity DataIC50:  1.08E+4nMAssay Description:Experimental method: hERG patch clamp detection methodExperimental procedure: Compound preparation: the stock solution of a compound was diluted with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM466958(Methyl 3-Chloro-4-(8-chloro- 3-((2,2-difluorocyclo...)
Affinity DataEC50:  230nMAssay Description:Experimental materials: HEK/mGluR2 cell line (human GluR2 transfected HEK cell line), DMEM (FBS) medium, positive control LY487379 (purchased from si...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent