BDBM467367 (R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(4-phenoxyphenyl)-4,5- dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide;::US10800792, Example 18::US10822348, Example 18

SMILES C=CC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccc(Oc5ccccc5)cc4)c(=O)[nH]c1c23

InChI Key

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 467367   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467367((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(4-phenox...)
Affinity DataKi:  32nMAssay Description:Inhibition of full length N-terminal GST-tagged human BTK expressed in Sf21 cells assessed as inhibition constant using NH2-KKKAPFSWYLPEEG as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467367((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(4-phenox...)
Affinity DataIC50:  63.1nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467367((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(4-phenox...)
Affinity DataIC50:  6.31nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467367((R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-(4-phenox...)
Affinity DataIC50:  6.31nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent