BDBM467711 (R)-5-(2-Methyl-4-phenoxyphenyl)-4-oxo-N-(1- (vinylsulfonyl)pyrrolidin-3-yl)-4,5-dihydro-3H-1-thia-3,5,8- triazaacenaphthylene-2-carboxamide;::US10800792, Example 369::US10822348, Example 834

SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)N[C@@H]4CCN(C4)S(=O)(=O)C=C)c([nH]c1=O)c23

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 467711   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467711((R)-5-(2-Methyl-4-phenoxyphenyl)-4-oxo-N-(1- (viny...)
Affinity DataIC50:  15.8nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467711((R)-5-(2-Methyl-4-phenoxyphenyl)-4-oxo-N-(1- (viny...)
Affinity DataIC50:  10nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK [386-659](Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467711((R)-5-(2-Methyl-4-phenoxyphenyl)-4-oxo-N-(1- (viny...)
Affinity DataIC50:  15.8nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent