BDBM468963 1-[1-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)tetrahydropyran-3-yl]pyrazol-4-yl]-N-[(3,5-dichlorophenyl)methyl]-3-hydroxy-2-oxo-pyrrolidine-3-carboxamide, isomer 1 hydrochloride::US10807971, Example 6
SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1cc(cn1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2)C1=O
InChI Key InChIKey=UYXAPGZGTCWPHK-PWXANOGISA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 468963
Affinity DataIC50: 1.91nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair
Affinity DataIC50: 123nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Affinity DataIC50: 261nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Affinity DataIC50: 0.474nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair