BDBM468975 1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)tetrahydropyran- 3-yl]triazol-4-yl]-N-[(3,5- dichloro-2-fluoro- phenyl)methyl]-3-hydroxy-2- oxo-pyrrolidine-3- carboxamide, isomer 1 hydrochloride::US10807971, Example 11

SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ncc(n1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2F)C1=O

InChI Key InChIKey=ODYUWKRIKQJPRU-WWQRYZTPSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 468975   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM468975(1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)t...)
Affinity DataIC50: <1.52nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethionine aminopeptidase 2(Mus musculus (Mouse))
Eli Lilly

US Patent
LigandPNGBDBM468975(1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)t...)
Affinity DataIC50:  12.8nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM468975(1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)t...)
Affinity DataIC50:  20.8nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Mus musculus)
Eli Lilly

US Patent
LigandPNGBDBM468975(1-[2-[(3R,5S,6R)-5-Amino-6- (2,5- difluorophenyl)t...)
Affinity DataIC50: <1.52nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent