BDBM468977 1-[2-[(3R,5S,6R)-5-Aamino- 6-(2,5- difluorophenyl)tetrahydropyran- 3-yl]-3,4-dihydropyrazol-3- yl]-N-[(3,5-dichloro-2-fluoro- phenyl)methyl]-3-hydroxy-2- oxo-pyrrolidine-3 carboxamide, isomer 1 hydrochloride::US10807971, Example 13
SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CCC(O)(C(=O)NCc2cc(Cl)cc(Cl)c2F)C1=O
InChI Key InChIKey=NILBVFCWAGNYNY-HLXUUHEFSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 468977
Affinity DataIC50: 3.27nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair
Affinity DataIC50: 10.6nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Affinity DataIC50: 2.03nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair