BDBM468979 1-[1-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)tetrahydropyran- 3-yl]pyrazol-3-yl]-N-[(3,5- difluorophenyl)methyl]-3- hydroxy-2-oxo-pyrrolidine-3- carboxamide, isomer 1 hydrochloride::US10807971, Example 15

SMILES N[C@H]1C[C@H](CO[C@@H]1c1cc(F)ccc1F)n1ccc(n1)N1CCC(O)(C(=O)NCc2cc(F)cc(F)c2)C1=O

InChI Key InChIKey=VKNVXZCIWXMZLT-WBIMGWQDSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 468979   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM468979(1-[1-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...)
Affinity DataIC50:  6.23nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethionine aminopeptidase 2(Mus musculus (Mouse))
Eli Lilly

US Patent
LigandPNGBDBM468979(1-[1-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...)
Affinity DataIC50:  30.5nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM468979(1-[1-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...)
Affinity DataIC50:  53.7nMAssay Description:The compounds exemplified herein are tested essentially as described below and exhibit an IC50 for the human and mouse MetAP2 assay as shown in Table...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Mus musculus)
Eli Lilly

US Patent
LigandPNGBDBM468979(1-[1-[(3R,5S,6R)-5-Amino- 6-(2,5- difluorophenyl)t...)
Affinity DataIC50:  7.73nMAssay Description:Human DPP-4 ((39-766)-His) and mouse DPP-4 ((29-760)-His) are purified by gel chromatography for use in the assay. The final concentration of hDPP-4 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent