BDBM468993 4-(1,1-dioxo-2,3-dihydro-1,2-benzothiazol-6-yl)- 2-methylisoquinolin-1-one::US10807982, Example 2

SMILES Cn1cc(-c2ccc3CNS(=O)(=O)c3c2)c2ccccc2c1=O

InChI Key InChIKey=AIIUUIKWQGOYQS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 468993   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM468993(4-(1,1-dioxo-2,3-dihydro-1,2-benzothiazol-6-yl)- 2...)
Affinity DataIC50:  2.75E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BREM was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent