BDBM469070 US10807974, Example 91::US10995088, Example 91::US11608330, Example 91

SMILES Cc1ccc(cc1)-c1cccc(c1)S(=O)(=O)c1cnc(CN)s1

InChI Key InChIKey=ACWFOKNSHMVIEB-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 469070   

TargetProtein-lysine 6-oxidase(Sus scrofa)
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  3.30E+3nMAssay Description:LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  70nMAssay Description:LOXL2 batch is obtained from R&D systems/Bio-techne. Incubate for 20 hours at room temp on a plate shaker.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  2.70E+4nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402, MAO-A Enzyme: Promega, Cat No. V1452.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  1.70E+4nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402, MAO-B Enzyme: Sigma, Cat No. M7441.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  3.30E+3nMAssay Description:The following reagents were prepared:Reagents500 mM CHES, pH 9 (with NaOH), filtered (MW=207.29)20.7 g in 200 ml in dH2O10% Pluronic F-127 (store at ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  1.70E+4nMAssay Description:Promega ROS-Glo H2O2 Assay Kit, 50 ml. Cat No. G8821Inhibitors (Test compounds):10 mM stock diluted to 10, 3, 1, 0.3, 0.1, 0.03, 0.01, 0.003, 0.001, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  2.70E+4nMAssay Description:The following reagents were prepared:ReagentsMAO-Glo Assay Kit: Promega, Cat No. V1402MAO-A Enzyme: Promega, Cat No. V1452Clorgyline: Sigma, Cat No. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  1.70E+4nMAssay Description:The following reagents were prepared:ReagentsMAO-Glo Assay Kit: Promega, Cat No. V1402MAO-B Enzyme: Sigma, Cat No. M7441Deprenyl: Sigma, Cat No. M003...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Sus scrofa)
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  3.30E+3nMAssay Description:LOX enzyme was obtained from pig skin by the method of Shackleton et al 1990.Assay Plates:Black, flat bottom 96 well platesProcedure:1. Dilute LOX en...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  70nMAssay Description:MAO-Glo Assay Kit: Promega, Cat No. V1402MAO-A Enzyme: Promega, Cat No. V1452Clorgyline: Sigma, Cat No. M3778 (50 mg)Assay Plates:96 well white polys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  2.70E+4nMAssay Description:MAO-B Enzyme: Sigma, Cat No. M7441Deprenyl: Sigma, Cat No. M003Assay Plates: 96 well white polystyrene, flat bottom plates, no lid: Fisher, Cat No. D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysyl oxidase homolog 2(Homo sapiens (Human))
The Institute Of Cancer Research: Royal Cancer Hospital

US Patent
LigandPNGBDBM469070(US10807974, Example 91 | US10995088, Example 91 | ...)
Affinity DataIC50:  70nMAssay Description:10. Incubate for 20 hrs at room temp on a plate shaker, protected from light.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent