BDBM469146 2-methyl-4-(5-methylsulfonyl-2-phenyl-1- benzofuran-7-yl)isoquinolin-1-one::US10807982, Example 26

SMILES Cn1cc(-c2cc(cc3cc(oc23)-c2ccccc2)S(C)(=O)=O)c2ccccc2c1=O

InChI Key InChIKey=ADKKKJSPASMXOK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 469146   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM469146(2-methyl-4-(5-methylsulfonyl-2-phenyl-1- benzofura...)
Affinity DataIC50: <500nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BREM was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent