BDBM469169 4-[7-(cyclopropylmethoxy)-4-ethylsulfonyl-2,3- dihydro-1,4-benzoxazin-6-yl]-2- methylisoquinolin-1-one::US10807982, Example 49

SMILES CCS(=O)(=O)N1CCOc2cc(OCC3CC3)c(cc12)-c1cn(C)c(=O)c2ccccc12

InChI Key InChIKey=PVWHOYFZJDGCRS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 469169   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM469169(4-[7-(cyclopropylmethoxy)-4-ethylsulfonyl-2,3- dih...)
Affinity DataIC50: <500nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BREM was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent