BDBM469187 5-(3-benzyl-2-methyl-7- methylsulfonylbenzimidazol-5-yl)-1,3- dimethylpyridin-2-one::US10807982, Example 67

SMILES Cc1nc2c(cc(cc2n1Cc1ccccc1)-c1cc(C)c(=O)n(C)c1)S(C)(=O)=O

InChI Key InChIKey=BJGXKKXNQDYOFZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 469187   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM469187(5-(3-benzyl-2-methyl-7- methylsulfonylbenzimidazol...)
Affinity DataIC50: <500nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BREM was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent