BDBM469208 8-[2-(cyclopropylmethoxy)-5- methylsulfonylphenyl]-1,1-difluoro-6-methyl-2,3- dihydroindolizin-5-one::US10807982, Example 89

SMILES Cc1cc(c2n(CCC2(F)F)c1=O)-c1cc(ccc1OCC1CC1)S(C)(=O)=O

InChI Key InChIKey=JBIORZORPDFQMV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 469208   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM469208(8-[2-(cyclopropylmethoxy)-5- methylsulfonylphenyl]...)
Affinity DataIC50:  2.75E+3nMAssay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BREM was cloned, expr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent