BDBM469261 (S)—N,N-dimethyl-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)-1-phenylmethanamine ::US10807985, Compound 36

SMILES CN(C)[C@@H](c1ccccc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(C)c1

InChI Key InChIKey=YWLPPCMADMRAKA-VWLOTQADSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 469261   

TargetMast/stem cell growth factor receptor Kit [D816V](Homo sapiens (Human))
Blueprint Medicines

US Patent
LigandPNGBDBM469261((S)—N,N-dimethyl-1-(2-(4-(6-(1-methyl-1H-pyra...)
Affinity DataIC50:  5.5nMAssay Description:In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V KIT (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (100 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent