BDBM470249 US10815206, Compound I-26::US11332451, Compound I-26::US11370764, Compound I-26::US11377428, Compound I-26

SMILES CN1c2cc(CCC(=O)NC3CC3)ccc2OC[C@H](NC(=O)c2ncn(Cc3ccccc3)n2)C1=O

InChI Key InChIKey=BZAQWBRJHJDEAH-FQEVSTJZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 470249   

TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470249(US10815206, Compound I-26 | US11332451, Compound I...)
Affinity DataIC50:  65.6nMAssay Description:A 500 ml stock volume of 5× Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470249(US10815206, Compound I-26 | US11332451, Compound I...)
Affinity DataIC50:  65.6nMAssay Description:A 500 ml stock volume of 5× Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470249(US10815206, Compound I-26 | US11332451, Compound I...)
Affinity DataIC50:  65.6nMAssay Description:ADP-Glo (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM470249(US10815206, Compound I-26 | US11332451, Compound I...)
Affinity DataIC50:  65.6nMAssay Description:A 500 ml stock volume of 5× Reaction Kinase Buffer was made by mixing 1000 μl of 1M MgCl2, 500 μl of 1M Tris-HCL pH7.4, 0.5 mg/ml (25 mg) o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent