BDBM470358 4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-N-(2-fluoro-6-methylphenyl)-2-[(2S)-pentan-2-yloxy]benzamide::US10815215, Example 17::US11130745, Example 17::US11713304, Example 17

SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(C)cccc1F)-n1nc(CC)n(C)c1=O

InChI Key InChIKey=QRBHBDOLPLEKQK-HNNXBMFYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 470358   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470358(4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...)
Affinity DataIC50:  6nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470358(4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...)
Affinity DataIC50:  1nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470358(4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...)
Affinity DataIC50:  1nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al. 196...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470358(4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...)
Affinity DataIC50:  1nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470358(4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...)
Affinity DataIC50:  6nMAssay Description:DHODH enzymatic assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470358(4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...)
Affinity DataIC50:  6nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent