BDBM470468 1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-[4-(4-chlorophenoxy)phenyl]-1H-pyrazole-4-carboxamide::US10815213, Example 130

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCCN(C1)C(=O)C=C

InChI Key InChIKey=HOUMQZGBNXSVNG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470468   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM470468(1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-[4-(4-...)
Affinity DataIC50:  7.90nMAssay Description:EGFR: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 20 μM ATP, 100 nM peptide subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM470468(1-[(3R)-1-acryloylpiperidin-3-yl]-5-amino-3-[4-(4-...)
Affinity DataIC50:  0.170nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent