BDBM470472 N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxymethyl)-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-2-[(2S)-pentan-2-yloxy]benzamide::US10815215, Example 135::US11130745, Example 135::US11713304, Example 135

SMILES CCC[C@H](C)Oc1cc(c(F)cc1C(=O)Nc1c(F)cccc1Cl)-n1nc(CO)n(C)c1=O

InChI Key InChIKey=BNCNDHIBUORLJG-LBPRGKRZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 470472   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470472(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...)
Affinity DataIC50:  3.20nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470472(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...)
Affinity DataIC50:  3.20nMAssay Description:DHODH enzymatic assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470472(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...)
Affinity DataIC50:  3.20nMAssay Description:The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller et al., 19...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent