BDBM470777 (1S,3'R,6'R,7'S,8'E,10'S,11'S)- 6-chloro-7'-((9aS)- hexahydropyrazino[2,1- c][1,4]oxazin-8(1H)-ylmethyl)- 7'-hydroxy-10',11'-dimethyl- 3,4-dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15'-one 13',13'-dioxide::US10821115, Example 164::US11224601, Example 164

SMILES C[C@@H]1CS(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@H]4[C@](O)(CN4CCN5CCCC[C@@H]5C4)\C=C\[C@@H]1C)c3c2

InChI Key InChIKey=ZAANKZNOCXZFPS-WMIVWLHWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470777   

LigandPNGBDBM470777((1S,3'R,6'R,7'S,8'E,10'S,11'S)- 6-chloro-7'-((9aS)...)
Affinity DataIC50:  0.0470nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470777((1S,3'R,6'R,7'S,8'E,10'S,11'S)- 6-chloro-7'-((9aS)...)
Affinity DataIC50:  0.0470nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent