BDBM470816 (1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-((2,2-dioxido-2- thia-6-azaspiro[3 .3]hept-6- yl)methyl)-7'-methoxy-11',12'- dimethyl-3,4-dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15'-one 13',13'-dioxide::US10821115, Example 202::US11224601, Example 202

SMILES CO[C@@]1(CN2CC3(C2)CS(=O)(=O)C3)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=XNTIVRODGKKFSW-LIWILRPNSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470816   

LigandPNGBDBM470816((1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-((2,2-...)
Affinity DataIC50:  0.0580nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470816((1S,3'R,6'R,7'S,8'E,11'S,12'R)- 6-chloro-7'-((2,2-...)
Affinity DataIC50:  0.0580nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent