BDBM470958 (1S,3'R,6'R,7'R,8'E,11'S,12'R)- 6-chloro-7'-(((3R,5S)-4-ethyl- 3,5-dimethyl-1- piperazinyl)methyl)-7'- methoxy-11',12'-dimethyl-3,4- dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15'-one 13',13'-dioxide::US10821115, Example 341::US11224601, Example 341

SMILES CCN1[C@@H](C)CN(C[C@@]2(OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)C[C@H]1C

InChI Key InChIKey=ATOIAIZNBMEOIY-CFICIXAPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 470958   

LigandPNGBDBM470958((1S,3'R,6'R,7'R,8'E,11'S,12'R)- 6-chloro-7'-(((3R,...)
Affinity DataIC50:  0.0520nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470958((1S,3'R,6'R,7'R,8'E,11'S,12'R)- 6-chloro-7'-(((3R,...)
Affinity DataIC50:  0.0520nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent