BDBM470958 (1S,3'R,6'R,7'R,8'E,11'S,12'R)- 6-chloro-7'-(((3R,5S)-4-ethyl- 3,5-dimethyl-1- piperazinyl)methyl)-7'- methoxy-11',12'-dimethyl-3,4- dihydro-2H,15'H- spiro[naphthalene-1,22'- [20]oxa[13]thia[1,14] diazatetracyclo [14.7.2.0~3,6~.0~19,24~] pentacosa[8,16,18,24]tetraen]- 15'-one 13',13'-dioxide::US10821115, Example 341::US11224601, Example 341
SMILES CCN1[C@@H](C)CN(C[C@@]2(OC)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)C[C@H]1C
InChI Key InChIKey=ATOIAIZNBMEOIY-CFICIXAPSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 470958
TargetBcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.0520nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Amgen
US Patent
Amgen
US Patent
Affinity DataIC50: 0.0520nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair