BDBM470979 (1S,3′R,6′R,7′R,8′E,11′S,12′R)-6-chloro-12′-((2S)-2-hydroxypropyl)-7′-methoxy-11′-methyl-7′-((9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-ylmethyl)-3,4-dihydro-2H,15′H-spiro[naphthalene-1,22′-[20]oxa[13]thia[1,14]diazatetracyclo[14.7.2.0-3,6˜.0˜19,24˜]pentacosa[8,16,18,24]tetraen]-15′-one 13′,13′-dioxide::US10821115, Example 362::US10821115, Example 363::US11224601, Example 363

SMILES CO[C@]1(CN2CCN3CCCC[C@@H]3C2)\C=C\C[C@H](C)[C@@H](C[C@@H](C)O)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=RQDBBRNOEPCGMG-IHGZHGPTSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 470979   

LigandPNGBDBM470979((1S,3′R,6′R,7′R,8′E,11R...)
Affinity DataIC50:  0.0610nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470979((1S,3′R,6′R,7′R,8′E,11R...)
Affinity DataIC50:  0.0800nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470979((1S,3′R,6′R,7′R,8′E,11R...)
Affinity DataIC50:  0.0610nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470979((1S,3′R,6′R,7′R,8′E,11R...)
Affinity DataIC50:  0.0800nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent