BDBM471794 5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperazin-1- yl]-2-methyl-3- oxo-propyl]-5- methyl- imidazolidine- 2,4-dione::US10829478, Compound 43

SMILES COc1cc(cc(F)c1F)N1CCN(CC1)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O

InChI Key InChIKey=VUBCFWBRGYOPKR-JEOXALJRSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 471794   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  37.5nMAssay Description:TABLE VI: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS4.For the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetADAMTS5(Rattus norvegicus (Rat))
Galapagos

US Patent
LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  12.5nMAssay Description:TABLE VII: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by rnADAMTS-5 (1-564-6H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  12.5nMAssay Description:TABLE IX: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:TABLE XIII: The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat #AS-27076) by human MMP13 (Enzo Life Scien...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:TABLE XI: The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID NO: 3) (Anaspec, custom 34891) by human TACE (R&D ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50: >1.00E+4nMAssay Description:TABLE XII: The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat #AS-27076) by human MMP13 (Chemicon, Cat #C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471794(5-[3-[4-(3,4- difluoro-5- methoxy- phenyl) piperaz...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent