BDBM471945 (5R)-5-[3-[(3S)-4- (4-chloro-2- methoxy- 5-methyl- phenyl)-3-methyl- piperazin- 1-yl]-3- oxo-propyl]-5- methyl- imidazolidine- 2,4-dione::US10829478, Compound 95

SMILES COc1cc(Cl)c(C)cc1N1CCN(C[C@@H]1C)C(=O)CC[C@@]1(C)NC(=O)NC1=O

InChI Key InChIKey=DTIPTQWBDZYKIH-RNODOKPDSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 471945   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471945((5R)-5-[3-[(3S)-4- (4-chloro-2- methoxy- 5-methyl-...)
Affinity DataIC50: >1.00E+4nMAssay Description:TABLE IX: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM471945((5R)-5-[3-[(3S)-4- (4-chloro-2- methoxy- 5-methyl-...)
Affinity DataIC50: >1.00E+4nMAssay Description:TABLE XI: The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID NO: 3) (Anaspec, custom 34891) by human TACE (R&D ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM471945((5R)-5-[3-[(3S)-4- (4-chloro-2- methoxy- 5-methyl-...)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent