BDBM472680 2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)-6,6a,9,10- tetrahydro-5H- pyrazino[1',2':1,6]pyrido[2,3- d]pyrimidine-5,7(8H)-dione::US10829490, Cmpd # 6

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3C(=O)CC4N(CCNC4=O)c3n2)nc1

InChI Key InChIKey=DZTLZHYVLZLORI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 472680   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM472680(2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...)
Affinity DataIC50:  1.44E+4nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM472680(2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...)
Affinity DataIC50:  5.04E+4nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM472680(2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM472680(2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM472680(2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM472680(2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM472680(2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Gi Therapeutics

US Patent
LigandPNGBDBM472680(2-((5-(4-methylpiperazin-1- yl)pyridin-2-yl)amino)...)
Affinity DataIC50: >1.00E+5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent