BDBM472762 2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide::US10829492, Example 39

SMILES CNC(=O)c1c(N)nn2ccc(nc12)N1C[C@@H](F)C[C@@H]1c1cc(F)ccc1F

InChI Key InChIKey=AJFFETASVVAJDG-GXFFZTMASA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 472762   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472762(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: <1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472762(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: <1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor [G667C](Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472762(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: <10nMAssay Description:TrkAG667C: TrkAG667C (Kinase domain) kinase was expressed in Sf9 cells (purchased from Invitrogen) using pIEX-Bac-4 (purchased from Merck), and purif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472762(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: <1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472762(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: >10nMAssay Description:JAK2: A testing platform for JAK2 kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF) assay, and the activities of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM472762(2-amino-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro...)
Affinity DataIC50: <1nMAssay Description:TrkA, TrkB and TrkC:A testing platform for TrkA, TrkB and TrkC kinase activity was established based on Homogeneous Time-Resolved Fluorescence (HTRF)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent