BDBM473683 1-tert-Butyl-3-[3-chloro-6- (methoxymethyl)-1H-indol-2-yl]-1H- pyrazolo[3,4-d]pyrimidin-4-amine::US10844067, Example 26::US11661423, Example 26

SMILES COCc1ccc2c(Cl)c([nH]c2c1)-c1nn(c2ncnc(N)c12)C(C)(C)C

InChI Key InChIKey=BFNZNEHBSBZTIV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 473683   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473683(1-tert-Butyl-3-[3-chloro-6- (methoxymethyl)-1H-ind...)
Affinity DataIC50:  21.9nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473683(1-tert-Butyl-3-[3-chloro-6- (methoxymethyl)-1H-ind...)
Affinity DataIC50: >3.00E+4nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473683(1-tert-Butyl-3-[3-chloro-6- (methoxymethyl)-1H-ind...)
Affinity DataIC50:  88.7nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473683(1-tert-Butyl-3-[3-chloro-6- (methoxymethyl)-1H-ind...)
Affinity DataIC50:  21.9nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473683(1-tert-Butyl-3-[3-chloro-6- (methoxymethyl)-1H-ind...)
Affinity DataIC50: >3.00E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473683(1-tert-Butyl-3-[3-chloro-6- (methoxymethyl)-1H-ind...)
Affinity DataIC50:  88.7nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent