BDBM473693 N-(trans-4-(4-Amino-3-(1H-pyrrolo[2,3- b]pyridin-2-yl)-1H-pyrazolo[3,4- d]pyrimidin-1- yl)cyclohexyl)cyclopropanecarboxamide::US10844067, Example 36::US11661423, Example 36

SMILES Nc1ncnc2n(nc(-c3cc4cccnc4[nH]3)c12)C1CC[C@@H](CC1)NC(=O)C1CC1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 473693   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473693(N-(trans-4-(4-Amino-3-(1H-pyrrolo[2,3- b]pyridin-2...)
Affinity DataIC50:  6.40nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473693(N-(trans-4-(4-Amino-3-(1H-pyrrolo[2,3- b]pyridin-2...)
Affinity DataIC50: >3.00E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473693(N-(trans-4-(4-Amino-3-(1H-pyrrolo[2,3- b]pyridin-2...)
Affinity DataIC50:  6.40nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473693(N-(trans-4-(4-Amino-3-(1H-pyrrolo[2,3- b]pyridin-2...)
Affinity DataIC50: >3.00E+4nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent