BDBM473699 1-Cyclobutyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyrazolo[3,4-d]pyrimidin-4-amine::US10844067, Example 42::US11661423, Example 42

SMILES Nc1ncnc2n(nc(-c3cc4cccnc4[nH]3)c12)C1CCC1

InChI Key InChIKey=CWVIHYJRRYYHDK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 473699   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473699(1-Cyclobutyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyr...)
Affinity DataIC50:  2.5nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473699(1-Cyclobutyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyr...)
Affinity DataIC50:  1.75E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473699(1-Cyclobutyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyr...)
Affinity DataIC50:  2.5nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM473699(1-Cyclobutyl-3-(1H-pyrrolo[2,3-b]pyridin-2- yl)pyr...)
Affinity DataIC50:  1.75E+3nMAssay Description:RET and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent