BDBM473825 3-(4-Cyanophenyl)-6,6-(3- tetrahydrofuran)-3,5,6,7- benzimidazolo-4-one::US10858342, Compound C-ABA-A

SMILES Clc1cc(ccc1C#N)-n1cnc2C[C@@]3(CCOC3)CC(=O)c12

InChI Key InChIKey=KDPULPOLUSRSSA-KRWDZBQOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473825   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473825(3-(4-Cyanophenyl)-6,6-(3- tetrahydrofuran)-3,5,6,7...)
Affinity DataIC50:  1.00E+6nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473825(3-(4-Cyanophenyl)-6,6-(3- tetrahydrofuran)-3,5,6,7...)
Affinity DataIC50:  16nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent