BDBM474109 6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 2::US10912773, Example 2::US11472810, Example 2

SMILES Fc1cccc(Cn2c(Cc3ccccc3)cn3c(ncc3c2=O)C2CCOCC2)c1

InChI Key InChIKey=NTXQTICQWIKNOO-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 474109   

LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  51nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  11nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  1.00E+4nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  51nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  51nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  14nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  11nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  51nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  14nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474109(6-Benzyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  11nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent