BDBM474131 7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 24::US10912773, Example 24::US11472810, Example 24

SMILES Cc1cn2c(ncc2c(=O)n1Cc1ccc(F)cc1)C1CCOCC1

InChI Key InChIKey=HTAKTLWSUKQRRS-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474131   

LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  38nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  43nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  38nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  43nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  17nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  38nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  43nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  38nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  43nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474131(7-(4-Fluorobenzyl)-6-methyl-3- (tetrahydro-2H-pyra...)
Affinity DataIC50:  17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent